RAF Typhoon jets have operated alongside French warplanes in a coordinated attack targeting an hidden munitions depot in Syrian territory operated by the IS group, according to the British defence ministry.
The site, identified by reconnaissance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to hit a series of access tunnels providing entry to the facility... initial indications are that the objective was successfully hit," officials stated.
There was no evidence of any civilian impact in the operation late on Saturday and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were backed up by a Voyager tanker plane.
IS - alternatively referred to as ISIS - imposed extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates British leadership, and resolve to work closely with our partners, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey said.
British military aircraft have performed patrols over Syria to "prevent any efforts to regroup" of Islamic State following its defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I must thank all the members of British forces participating in this strike for their skill and their bravery," the Defence Secretary said. "They were among numerous British personnel stationed over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our way of life, demonstrates how UK forces are prepared to act, throughout the year, protecting the UK at home and strong abroad."
In December, the American forces executed what it termed a "major assault" against IS targets in Syria, following an ambush killed two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still maintains between 5,000 and 7,000 combatants in Syria and Iraq.